Search results for " fasting"

showing 10 items of 60 documents

Fasting and "Fasting mimicking diet" (FMD) an effective intervention to promote longevity and health span

Settore MED/04 - Patologia GeneraleAgeingFasting; Ageing; Longevity; Microbiota; Fasting-mimicking diet; NutritionMicrobiotaLongevityFasting-mimicking dietFastingNutrition
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Glucose regulation and pain in older people-The Helsinki Birth Cohort Study

2021

Aims: To assess if individuals with diabetes or prediabetes report more pain or have increased use of pain medication compared to normoglycaemic individuals. Methods: Using cross-sectional data, we studied 928 men and 1075 women from the Helsinki Birth Cohort Study in 2001-2004 at a mean age of 61.5 years. Glucose regulation was assessed with a 2-h 75 g oral glucose tolerance test, and applying World Health Organization criteria, participants were defined as having normoglycaemia, prediabetes (impaired fasting glucose or impaired glucose tolerance), newly diagnosed diabetes or previously diagnosed diabetes. Self-reported pain intensity and interference during the previous 4 weeks was estima…

Blood GlucoseMalePREDICTOREpidemiologyIMPACTEndocrinology Diabetes and MetabolismglukoosiaineenvaihduntaprediabetesDISEASECohort StudiesImpaired glucose tolerance0302 clinical medicinepain030212 general & internal medicinePrediabetesepidemiologiaPOPULATION2. Zero hungereducation.field_of_studyNutrition and DieteticsdiabetesDiabetesMiddle Aged3. Good healthPREVALENCEFemaleepidemiologyFamily Practiceikääntyneetmedicine.medical_specialtyPopulationPain030209 endocrinology & metabolismPrediabetic State03 medical and health sciencesInternal medicineDiabetes mellitusGlucose IntoleranceInternal MedicinemedicineHumansTOLERANCEeducationAgedbusiness.industryBeck Depression Inventorykipumedicine.diseaseImpaired fasting glucoseLIFEHIGH-RISKCross-Sectional StudiesGlucose3121 General medicine internal medicine and other clinical medicinekrooninen kipuBlood sugar regulationbusinessBody mass indexPrediabetesPERIPHERAL NEUROPATHY
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Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression

2016

SummaryImmune system defects are at the center of aging and a range of diseases. Here, we show that prolonged fasting reduces circulating IGF-1 levels and PKA activity in various cell populations, leading to signal transduction changes in long-term hematopoietic stem cells (LT-HSCs) and niche cells that promote stress resistance, self-renewal, and lineage-balanced regeneration. Multiple cycles of fasting abated the immunosuppression and mortality caused by chemotherapy and reversed age-dependent myeloid-bias in mice, in agreement with preliminary data on the protection of lymphocytes from chemotoxicity in fasting patients. The proregenerative effects of fasting on stem cells were recapitula…

0301 basic medicinemedicine.medical_specialtyhematopoietic regenerationfastingmedicine.medical_treatmentCellBiologyMice03 medical and health sciences0302 clinical medicineImmune systemSettore BIO/13 - Biologia ApplicataInternal medicinemedicineGeneticsAnimalsRegenerationInsulin-Like Growth Factor I030304 developmental biologyImmunosuppression Therapy0303 health sciencesstem cells; fasting; nutrition; hematopoietic regenerationRegeneration (biology)Hematopoietic stem cellImmunosuppressionCell BiologyHematopoietic Stem CellsCyclic AMP-Dependent Protein Kinases3. Good healthCell biologyMice Inbred C57BLstem cellHaematopoiesisEndocrinologynutrition030104 developmental biologymedicine.anatomical_structure030220 oncology & carcinogenesisMolecular MedicineSignal transductionStem cellCell Stem Cell
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Classical cardiovascular risk factors according to fasting plasma glucose levels

2007

To compare the prevalence of classical cardiovascular risk factors (CVRF) and metabolic syndrome (MetS) in our population according to fasting plasma glucose levels (FPG).We have studied 344 subjects between 20-70 years of age, recruited in a Primary Care Clinic. Subjects were divided into four groups according to their fasting plasma glucose (FPG) values: normal plasma glucose (NG) when FPG5.6 mmol/L; FPG between 5.6 and 6.0 mmol/L (FPG1); FPG between 6.1-6.9 mmol/L (FPG2); and diabetes (DM) FPGor = 7 mmol/L or previous diagnosis of diabetes. Cardiovascular risk factors (hypertension, TC/HDL-C index and Apo B values), presence of the MetS and indirect measure of insulin resistance (HOMA) w…

AdultBlood GlucoseMalemedicine.medical_specialtyendocrine system diseasesPopulationCardiovascular risk factorsComorbiditySeverity of Illness IndexRisk FactorsInternal medicinePrevalenceInternal MedicinemedicineHumanseducationPractical implicationsAgedMetabolic Syndromeeducation.field_of_studyPlasma glucosebusiness.industrynutritional and metabolic diseasesType 2 Diabetes MellitusFastingMiddle AgedImpaired fasting glucosemedicine.diseasePrimary care clinicCross-Sectional StudiesEndocrinologyDiabetes Mellitus Type 2Cardiovascular DiseasesSpainFemaleMetabolic syndromebusinessEuropean Journal of Internal Medicine
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Use of the Diabetes Risk Score for Opportunistic Screening of Undiagnosed Diabetes and Impaired Glucose Tolerance

2005

OBJECTIVE—To evaluate an opportunistic screening strategy addressed to individuals with one or more cardiovascular risk factor, based on the Diabetes Risk Score (DRS) as the initial instrument, for the identification of individuals with type 2 diabetes or impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS—The DRS, a simple self-administered questionnaire, was completed by individuals identified by general practitioners and presenting with one or more cardiovascular risk factor. All patients underwent a 2-h oral glucose tolerance test (OGTT). The optimal DRS cutoff was calculated by applying the receiver-operating characteristic curve. RESULTS—Overall, 1,377 individuals aged betwe…

medicine.medical_specialtyDiabetes riskEndocrinology Diabetes and MetabolismType 2 diabetesImpaired glucose toleranceMELLITUSNIDDMPEOPLEInternal medicineDiabetes mellitusInternal MedicinemedicineRisk factorProspective cohort studyAdvanced and Specialized NursingGlucose tolerance testmedicine.diagnostic_testbusiness.industryPERFORMANCEmedicine.diseaseImpaired fasting glucosePREVENTIONPREVALENCEEndocrinologyLIFE-STYLEHEALTHbusinessDiabetes Care
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Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes.

2020

Background: Naturally occurring variation in Membrane-bound O-acyltransferase domain-containing 7 (MBOAT7), encoding for an enzyme involved in phosphatidylinositol acyl-chain remodelling, has been associated with fatty liver and hepatic disorders. Here, we examined the relationship between hepatic Mboat7 down-regulation and fat accumulation. Methods: Hepatic MBOAT7 expression was surveyed in 119 obese individuals and in experimental models. MBOAT7 was acutely silenced by antisense oligonucleotides in C57Bl/6 mice, and by CRISPR/Cas9 in HepG2 hepatocytes. Findings: In obese individuals, hepatic MBOAT7 mRNA decreased from normal liver to steatohepatitis, independently of diabetes, inflammatio…

Research paperTGFβ Transforming Growth Factor BetaIntracellular SpaceCRISPR Clustered Regularly Interspaced Short Palindromic RepeatshHEPS Human HepatocytesMice0302 clinical medicineLPIAT1DAG Diacylglyceroli.p. Intraperitonealmedia_commonFatty AcidsGeneral Medicine3. Good health030220 oncology & carcinogenesisHOMA-IR homeostasis Model Assessment of Insulin ResistanceMPO morpholinolcsh:Medicine (General)medicine.medical_specialtyPE Phosphatidyl-EthanolamineNashGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciencesTNFα tumor Necrosis Factor AlphaLDL Low Density LipoproteinsHyperinsulinismNAFLDSD Standard Dietmedia_common.cataloged_instanceHumansCPT1 Carnitine Palmitoyltransferase IPhosphatidylinositolGene SilencingEuropean unionVLDL Very Low Density Lipoproteinlcsh:RhHSC Human Hepatic Stellate Cellsmedicine.diseaseLipid MetabolismOA Oleic AcidCI Confidence IntervalMboat7 Membrane bound O-acyltransferase domain containing 7MCD methionine choline deficient diet030104 developmental biologyEndocrinologychemistryCDP Cytidine-DiphosphateFOXO1 Forkhead Box protein O1NAFLD nonalcoholic fatty liver diseaseSteatohepatitisBMI Body Mass IndexCL CardiolipinAcyltransferases0301 basic medicineAlcoholic liver diseaseCXCL10 C-X-C Motif Chemokine 10lcsh:Medicinechemistry.chemical_compoundNon-alcoholic Fatty Liver DiseaseIFG Impaired Fasting GlucoseAPOB Apolipoprotein BNonalcoholic fatty liver diseasePIP Phosphatidyl-Inositol-PhosphateSteatohepatitisqRT-PCR quantitative Real Time Polymerase Chain ReactionMice Knockoutlcsh:R5-920ORO Oil Red O StainingPI PhosphatidylinositolFatty liverTM6SF2 Transmembrane 6 Superfamily Member 2PhospholipidTAG TriglyceridesNASH Nonalcoholic SteatohepatitisLipogenesisLPA Lyso-Phosphatidic AcidPhosphatidylinositolSignal TransductionPS Phosphatidyl-SerinePA Palmitic AcidALD alcoholic liver diseasePC Phosphatidylcholinei.v. IntravenousFATP1 Fatty Acid Transport Protein 1Models BiologicalInternal medicinemedicineAnimalsNonalcoholic fatty liver diseasePPARα Peroxisome Proliferator-Activated Receptor alphaObesityG3P Glyceraldehyde-3-PhosphateSREBP1c Sterol Regulatory Element-Binding Protein 1HDL High Density Lipoproteinsbusiness.industryPI3K Phosphatidylinositol 3 KinaseMembrane ProteinsNHEJ Non-Homologues End JoiningPNPLA3 Patatin-like Phospholipase Domain-containing-3MTTP Microsomal Triglyceride Transfer ProteinLPIAT1 Lysophosphatidylinositol Acyltransferase 1TMC4 Transmembrane Channel-Like 4Disease Models AnimalGene Expression RegulationHepatocytesFOXA2 Forkhead Box A2mTOR mammalian target of RapamycinSteatosisInsulin ResistancebusinessPG Phosphatidyl-GlycerolFABP1 Fatty Acid-Binding Protein 1 FAS Fatty Acid SynthaseT2DM Type 2 Diabetes MellitusEBioMedicine
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Time-Restricted Feeding and Metabolic Outcomes in a Cohort of Italian Adults.

2021

Background: research exploring the effects of food timing and frequency on health and disease is currently ongoing. While there is an increasing body of scientific literature showing the potential health benefits of intermittent fasting (IF) in laboratory settings and in animals, studies regarding IF on humans are limited. Therefore, the objective of this research was to evaluate the relationship between the feeding/fasting time window and metabolic outcomes among adult individuals. Methods: dietary and demographic data of 1936 adult subjects living in the south of Italy were examined. Food frequency questionnaires (FFQ) were administered to determine the period of time between the first an…

AdultMaletime-restricted feedingobesityTime FactorshypertensionMediterranean dietfastingOverweightMediterraneanDiet MediterraneanArticlemetabolicMediterranean dietIntermittent fastingmedicineDiabetes MellitusHumansTX341-641Settore MED/49 - Scienze Tecniche Dietetiche ApplicateDyslipidemiasMealNutrition and Dieteticsbusiness.industryNutrition. Foods and food supplyintermittent fastingConfoundingdyslipidemiabreakfastFeeding BehaviorcohortMiddle Agedmedicine.diseaseObesityDietCross-Sectional StudiesNutrition AssessmentDiabetes Mellitus Type 2ItalyCohortFemalemedicine.symptombusinessDyslipidemiaType 2Food ScienceDemographyNutrients
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Intermittent Fasting and the Possible Benefits in Obesity, Diabetes, and Multiple Sclerosis: A Systematic Review of Randomized Clinical Trials

2021

Intermittent fasting has become popular in recent years and is controversially presented as a possible therapeutic adjunct. A bibliographic review of the literature on intermittent fasting and obesity, diabetes, and multiple sclerosis was carried out. The scientific quality of the methodology and the results obtained were evaluated in pairs. Intermittent fasting has beneficial effects on the lipid profile, and it is associated with weight loss and a modification of the distribution of abdominal fat in people with obesity and type 2 diabetes as well as an improvement in the control of glycemic levels. In patients with multiple sclerosis, the data available are too scarce to draw any firm con…

obesitymedicine.medical_specialtyMultiple SclerosisGlycemic ControlReviewType 2 diabeteslaw.inventionRandomized controlled trialWeight losslawDiabetes mellitusIntermittent fastingHumansMedicineTX341-641Intensive care medicineRandomized Controlled Trials as TopicGlycemicNutrition and Dieteticsexercisemedicine.diagnostic_testNutrition. Foods and food supplyintermittent fastingbusiness.industryFastingmedicine.diseaseObesityDiabetes Mellitus Type 2type 2 diabetesmedicine.symptombusinessLipid profileFood ScienceNutrients
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Visceral adiposity index and DHEAS are useful markers of diabetes risk in women with polycystic ovary syndrome

2014

ObjectiveOn the basis of the known diabetes risk in polycystic ovary syndrome (PCOS), recent guidelines of the Endocrine Society recommend the use of an oral glucose tolerance test (OGTT) to screen for impaired glucose tolerance (IGT) and type 2 diabetes (T2DM) in all women with PCOS. However, given the high prevalence of PCOS, OGTT would have a high cost–benefit ratio. In this study, we identified, through a receiver operating characteristic analysis, simple predictive markers of the composite endpoint (impaired fasting glucose (IFG) or IGT or IFG+IGT or T2DM) in women with PCOS according to the Rotterdam criteria.DesignWe conducted a cross-sectional study of 241 women with PCOS in a unive…

AdultBlood Glucosemedicine.medical_specialtyDiabetes riskWaistendocrine system diseasesAdolescentEndocrinology Diabetes and MetabolismType 2 diabetesIntra-Abdominal FatSettore MED/13 - EndocrinologiaImpaired glucose toleranceYoung AdultInsulin resistanceEndocrinologyAdiposity; Adolescent; Adult; Biological Markers; Blood Glucose; Cross-Sectional Studies; Diabetes Mellitus Type 2; Female; Humans; Intra-Abdominal Fat; Polycystic Ovary Syndrome; Risk Factors; Young Adult; Endocrinology; Endocrinology Diabetes and Metabolism; Medicine (all)Risk FactorsInternal medicineDiabetes mellitusmedicineHumansAdiposityCross-Sectional Studiebusiness.industryRisk FactorMedicine (all)nutritional and metabolic diseasesGeneral MedicineImpaired fasting glucosemedicine.diseasePolycystic ovaryCross-Sectional StudiesEndocrinologyDiabetes Mellitus Type 2Biological MarkerFemalebusinessBiomarkersHumanPolycystic Ovary Syndrome
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Spanish population trends in Internet searches for information on different diets

2019

Abstract Objective To use Google Trends to explore the trends of interest of the Spanish population regarding information related to different types of diets, focused on those that are popular and with evidence-based studies, over the last 10 years. Material and methods The search trends referred to the terms “Mediterranean diet”, “ketogenic diet”, “low fat diet”, “intermittent fasting” and “vegan diet” were analyzed. The relative search volumes (RSV) of the terms were compared. The direction of the trend was studied using the Spearman's correlation coefficient (SC). Results “Mediterranean diet” was the most widely searched term, with a median RSV of 16 (interquartile range [IQR] 6; range 8…

020205 medical informaticsMediterranean dietmedicine.medical_treatmentPopulation02 engineering and technology03 medical and health sciences0302 clinical medicineAnimal scienceInterquartile rangeIntermittent fasting0202 electrical engineering electronic engineering information engineeringHumansMedicine030212 general & internal medicineeducationInterneteducation.field_of_studyConsumer Health Informationbusiness.industryVegan DietLow fat dietDietSpanish populationSpainbusinessKetogenic dietEndocrinología, Diabetes y Nutrición (English ed.)
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